MPO (+), NSE weakly + (25%)

CD33, 13, 117, 64 (+)

HLA-DR, CD34, 11a, 11b, 18, 15, 65 (-)

bcr3: CD34, 2 (+)

CD2: related to FLT3-ITD

CD56: expressed in 10% of APL cases, worse outcome

Hypergranular

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/f9a99263-955d-48f9-a377-5dd969512f10/untitled

Acute promyelocytic leukemia. (A) Marrow film. Leukemic promyelocytes. Mononuclear cells with numerous cytoplasmic reddish granules. (B) Marrow film. Leukemic promyelocytes. Most cells have numerous cytoplasmic reddish-purple granules. Cells vary in nuclear cytoplasmic ratio ranging from high to intermediate. Note tendency of nuclei to take on shape characteristic of myelocyte or metamyelocyte, perhaps reflecting the desultory maturation that can be seen in this leukemia.

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/942c776b-dc6e-40a3-b2ec-ba67bcae5994/IMG_9483.jpg

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/3e138eec-7641-4fea-b35c-0ddfcac3c4de/IMG_9484.jpg

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/7cc36360-7eb2-4163-b420-07cb092b138d/IMG_9486.jpg

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/d95a9cab-1073-4ed0-bd5f-bf8b0a1557fd/IMG_9485.jpg

Dumbell-shaped

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/c432b963-8946-4fe7-bf0a-1b840122285d/IMG_9487.jpg

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/ffbf606a-bbb0-4106-a580-83a3ace86abf/IMG_9588.jpg

Hypogranular variant

https://s3-us-west-2.amazonaws.com/secure.notion-static.com/417b9c59-27cf-46cf-9428-add0584ae485/IMG_0228.jpg

許維軒 - high risk, CNS relapse