Which of the following associations between infectious agents and lymphoma subtypes is WRONG?

(A) Human T lymphotrophic virus I (HTLV 1) and adult T cell leukemia/lymphoma

(B) Helicobacter pylori and gastric MALToma

(C) Hepatitis C virus and angioimmunoblastic T cell lymphoma

(D) Epstein Barr virus and Hodgkin lymphoma

(E) Chlamydia psittaci and ocular adnexal lymphoma

Hodgkin lymphoma

A 35 years old woman has suffered from generalized itching for two months. Recently, she also has had mild dysphagia. CXR revealed anterior mediastinal widening, which following malignancy is most likely?

• Small cell lung cancer
• Extragonadal dysgerminoma
• Non-Hodgkin’s lymphoma
• Hodgkin’s lymphoma
• Thymoma

有關復發頑固型何杰金氏淋巴瘤，有許多臨床治療上應注意事項，下列敘述何者正確?

1. Brentuximab vedotin (BV) 不宜合併 bleomycin 使用，因為容易發生間質性肺炎。
2. 自體幹細胞移植為常用救援治療， 若以 BV 合併移植，BV 宜維持治療 16 個療程。
3. BV 合併 anti PD-1 治療 其整體反應率可達 7-8 成。
4. 高危險因子定義包含 12 個月內復發，第一線治療效果為 partial response 或 stable disease ，淋巴結外復發，B 症狀，經兩線藥物治療後等，有其中一項就屬於高危險群。