Bone Marrow Aspirate showing megaloblastic erythropoeisis with very fine nuclear chromatin and asynchrony of development of nucleus (immature) and cytoplasm (more mature).
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/a9d98392-4166-47f4-9302-50a0fa465e8a/untitled
Bone marrow aspirate from a patient with folic acid deficiency is shown. There is an erythroid hyperplasia with marked nuclear/cytoplasmic dysynchrony noted at all stages of erythroid maturation. Maturing erythroid precursor in the center of the slide shows nuclear budding.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/c77ccf2a-f500-4476-ad4a-cb681f832086/untitled
Marked megaloblastic changes seen in all stages of erythroid maturation: nuclear-cytoplasmic dysynchrony, open nuclear chromatin, and nuclear budding. Overall there is a decreased M:E ratio (myeloid to erythroid) secondary to a marked erythroid hyperplasia.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/c6f39201-0bb8-4f3d-9956-1b3a8029311d/untitled
At a higher magnification of previous image the open, sieve-like chromatin (salt and pepper) pattern in nucleus of megaloblastic cells is apparent. Howell-Jolly Bodies can be seen in orthochromatic nucleated red blood cells. Nuclear budding is seen on the orthochromatic cell.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/30ca3999-4771-45d7-bbe1-149275542b9c/untitled
Myeloid cells showing megaloblastic changes. Two giant bands are seen on the left of the field. One of these has features referred to as a “kissing band." In the right upper corner of the field a late erythroid form with nuclear budding is noted.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/c8912cd8-5e9a-4db4-a5d3-a49c34da3c0d/untitled
A megakaryocyte with markedly increased nuclear lobulation is shown.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/c00bb82b-93b3-485a-8159-8679cbc95263/untitled
Megaloblastic erythroid precursors with open chromatin pattern.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/9725566d-9b4d-4779-9b91-debf9245d8b2/untitled
Proerythroblasts may be large with an attenuated chromatin pattern.
https://s3-us-west-2.amazonaws.com/secure.notion-static.com/3bcff82d-28e4-4e4e-92cb-0159ce5554ce/untitled