Aplastic Anemia

• Moderate aplastic anemia — The criteria for moderate AA include:
  • Bone marrow cellularity <30 percent
  • Absence of severe pancytopenia
  • Depression of at least two of three blood elements below normal
• Severe aplastic anemia — The criteria for severe aplastic anemia (SAA) are:
  • A bone marrow biopsy showing <25 percent of normal cellularity, or
  • A bone marrow biopsy showing <50 percent normal cellularity in which fewer than 30 percent of the cells are hematopoietic and at least two of the following are present: absolute reticulocyte count <40,000/microL; absolute neutrophil count (ANC) <500/microL; or platelet count <20,000/microL.
• Very severe aplastic anemia — The patient is considered to have very severe aplastic anemia (vSAA) if the criteria for severe aplastic anemia are met and the ANC is <200/microL

Lymphoma

Lugano Classification

Stage IIIE → stage IV

If PET (-) in DLBCL → BM bx (2.5cm)

Diffuse large B cell lymphoma - IPI

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Follicular (FLIPI) (compared to IPI)

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PRIMA-PI

Hodgkins Disease