• The T-cell lymphomas account for approximately 5%–10% of all NHL.
  • More common in Asia, 10-20% of NHL.
• The median age at diagnosis is 59 years, which is lower than the median age of 66 for patients with NHL in general.
• Male:female = 2:1.
• Globally the three most common subtypes of PTCL are PTCL-NOS (25.9%), AITL (18.5%), and ALCL (12%).
  • PTCL-NOS more common in North America.
  • AITL and EATL more common in Europe.
• The median time from diagnosis to relapse or progression of disease after primary therapy was 6.7 months.
• The median overall survival and second progression-free survival were only 5.5 and 3.1 months, respectively.

Major Types of Mature T-Cell Lymphomas

Highlights of changes in 2016 WHO classification of lymphoid, histiocytic, and dendritic neoplasms

Incidence

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Pathobiology

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Diagnosis

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Prognosis